Apoptotic Vesicles Regulate Bone Metabolism via the miR1324/SNX14/SMAD1/5 Signaling Axis (Small 16/2023)

Cell-Free Therapies hBMMSC-apoVs can promote mesenchymal stem cell (MSC) osteogenesis and inhibit osteoclast formation in vitro vivo. The mechanisms include the release of miR1324, which inhibits expression target gene SNX14, thereby activating SMAD1/5 pathway cells. In article number 2205813, Xiao Zhang, Yunsong Liu, co-workers suggest a therapeutic strategy for treatment bone loss, including tissue engineering through cell-free approach.